News
NextGen aims to develop tools for advance diagnostics, prediction and personalised medicine for cardiovascular disease, using sensitive data and information located at multiple sites. The sensitive nature of these data requires tools that search for multimodal datasets without letting the native information leave the site where it is stored and managed. NextGen’s federated catalogue is a decentralized discovery […]
In the NextGen project, the Multimodal Integration Object (MMIO) is a key innovation that enables the integration of complex health datasets—clinical, imaging, wearable, phenotypic, and genomic—into a single, semantically rich, and interoperable data object, essential for personalised cardiovascular medicine. An MMIO is built on structured schemas that link data to transformation events, policies, and agreements. It ensures immutability, […]
Genomic sequencing reveals the full DNA sequence of an individual, uncovering millions of genetic variants—small differences in the nucleotide sequence that make each person unique. Among these, some variants occur in genes or regulatory regions and may influence health or disease. But identifying a variant in the genome is only the beginning. The real challenge […]
Genome curation involves a series of steps that integrate genomic data with validated experimental evidence and literature from diverse databases. Effective data curation and quality control are essential to ensure the accuracy, consistency, and reliability of genomic analysis results. In this context, NextGen genomic tools will focus on several aspects. Accelerating genomic data analysis pipelines. Through […]
Genomic data curation is a particularly important component of the NextGen toolbox. Data curation is a process to ensure accuracy, consistency, and usability of genomic data by addressing structural and content-related issues – such as missing, invalid, or inconsistent entries. Manual curation processes are very time-consuming and difficult to scale because of the size and […]
NextGen is a Horizon Europe research initiative, co-funded by UKRI (United Kingdom) and SERI (Switzerland) that develops multimodal, multiomic data integration, i.e. and federated analytics in personalised cardiovascular medicine. Multimodal data combine different data formats – text, images, audio, or sensor readings – from varied sources or technologies, to provide a richer analytical perspective, while multiomic data integrate distinct biological […]
The NextGen Project is organising a roundtable discussion during the DIA Europe 2025 annual meeting to explore and assess genomic penetrance to diversity and bias in datasets. DIA is the Drug Information Organisation operating globally. The Roundtable exercise will explore key issues related to penetrance and disease expression, particularly how the composition of individuals enrolled […]
Our NextGen project is actively participating in the DIA Europe 2025 annual meeting, taking place from 18 to 20 March 2025 in Basel, Switzerland. DIA Global – Drug Information Organisation is partner in the NextGen project and the leading global multidisciplinary life science membership association, which drives collaboration in drug, device, and diagnostic development in pursuit of a healthier world. […]
Are you passionate about unlocking the complexities of genetics? Do you want to contribute to the NextGen project, where we are developing innovative and synergistic tools for portable multimodal, multiomic, and clinically oriented research in high-impact areas of cardiovascular medicine? UMC Utrecht has two exciting opportunities available: Both positions are based in the vibrant city of […]
Do you want to contribute to top quality medical research? We are looking for a postdoctoral researcher to join our team Translational Vascular Medicine. The Department of Molecular Medicine and Surgery (MMK) carries out both preclinical and clinical research within numerous fields. Linked to the Department are approximately 450 researchers, postgraduate students, teachers and technical […]