The cost of whole exome and whole genome sequencing continues to fall, so that the bottleneck in the clinical adoption of genomics-based precision medicine has shifted from data generation to data analysis. Genomic data analysis is a computationally intensive process with multiple processing steps. With the amount of genomic data growing “exponentially” it becomes increasingly difficult to perform such an analysis in a timely and cost-efficient manner. In NextGen we develop several open-source hardware-independent approaches for accelerated genomic data analysis to enhance the integration of genomic data in multimodal contexts.